This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. A comparative genome analysis of L. Structural relationships between small ss-pore-forming toxins from Clostridium perfringens 28. Unfortunately, he passed away on March 20, 2014, but his contribution to science will continue. Want to get more out of the basic search box? Helicobacter pylori vacuolating toxin Introduction The vacA gene and its product VacA structure Interaction with host cells Biological activities of VacA Conclusion Acknowledgments References 20.
Popoff, Instit Pasteur, Unité des Bactéries anaérobies et Toxines, Paris, France. Alouf was the main force behind the writing of Comprehensive Sourcebook of Bacterial Protein Toxins. He is also the co-editor of several books. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Keywords Modular protein toxins; horizontal gene transfer; toxin evolution; pathogenicity island; secretion system effector; recombination; transmission; genetic exchange; phage; plasmid; pathoadaptation Introduction It has long been believed that microbes capable of causing human disease evolve over long periods of time through complex interactions between the microbes and their hosts.
Bordetella protein toxins -- Ch. He served as Secretary General of the French Society of Immunology from 1984-1986 and President of the Federation of the European Microbiological Societies from 1989-1992. Mobile genetic elements and pathogenicity islands encoding bacterial toxins -- Ch. Pathogenic bacteria establish infections in widely diverse host environments, ranging from the skin to various mucosal surfaces, such as the oral cavity, lungs, gut, and vagina. Basic knowledge gained on the mechanisms of CyaA entry into eukaryotic target cells and its interaction with cellular effectors has been used to develop various applications in vaccinology and biotechnology.
Library of Congress Cataloging-in-Publication Data A catalog record for this book is available from the Library of Congress. The E-mail message field is required. Several are amongst the most potent biological agents known to man. By combining molecular genetics, biochemical and biophysical approaches, he has characterized the structure, function and biogenesis of the CyaA toxin, with a particular emphasis on deciphering the molecular basis of its original entry pathway that involves a direct translocation of its catalytic domain across the plasma membrane. Fraser, School of Medical Sciences, University of Auckland and Maurice Wilkins Centre, Auckland, New Zealand Teresa Frisan, Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden Jorge E. This edition, coming out nine years after the last one, is in keeping with this series, with the main objective to update recently acquired knowledge on both previously known and newly discovered toxins, to describe their common features which allow a better understanding of their evolution and their role in the pathogenesis, and to highlight novel applications that have emerged over the past decade.
Each of the previous editions of this book have included the most recent advances of this rapidly moving world of toxins. He is member of the French Veterinary Academy. In 2011, a large outbreak of diarrhea and hemolytic-uremic syndrome occurred in Germany due to an unusual, highly virulent strain of enteroaggregative hemorrhagic E. Alouf is Professor of Microbiology at the Pasteur Institute of Lille. Botulinum toxin has now of course found clinical application as botox, and anthrax, and other toxins, have potentially devastating effects if misused as an agent of biological terror. Phage induction may also contribute to the release of toxins when specific protein secretion systems do not exist for the toxin, or when the toxin is too large for efficient export. Although they are not toxins per se, these effector proteins can be considered as such since they mediate cytopathic or cytotoxic effects in host cells upon being directly delivered to the host cell cytosol by the secretion apparatus.
In many cases, it is the toxin produced and not the infectious agent itself that causes pathology. Inhibitors of pore-forming toxins 39. . In the recent years, we have analyzed the molecular mechanism of the actin depolymerizing C. Vibrio parahaemolyticus virulence determinants 9.
Indeed, these molecules produced by pathogenic and environmental bacteria are extremely diverse in terms of their composition, structure, size, biochemical properties, and mode of interaction with target cells. The Comprehensive Sourcebook of Bacterial Protein Toxins 4 th Edition, contains chapters written by internationally known and well-respected specialists. Two CyaA-based recombinant vaccines are currently evaluated in clinical trials. Aerolysin and Related Aeromonas Toxins Introduction Production, purification, and primary sequence Structure of proaerolysin Secretion of proaerolysin Receptor binding From the precursor to the active toxin Heptamer formation Membrane insertion and channel properties Cellular consequences of aerolysin Aerolysin as a tool Concluding remarks Acknowledgments References 27. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This book and the individual contributions contained in it are protected under copyright by the Publisher other than as may be noted herein.
This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Clostridial neurotoxins: from the cellular and molecular mode of action to their therapeutic use 12. This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century, illustrated by the discovery of more than fifty novel toxins many of them identified through genome screening. He was co-editor of the 3 Degrees edition of the Sourcebook of Bacterial Protein Toxins Academic Press 2006. Engineering of bacterial toxins for research and medicine 36. This course was very appreciated by the students, and J. He has published more than 90 articles in peer-reviewed journals, 20 review articles or Book chapters and co-authored 11 patents.