However, there is little insight into how the signal is moved retrogradely. Expression of nerve growth factor in the airways and its possible role in asthma V. Levi-Schaffer, Nerve growth factor displays stimulatory effects on human skin and lung fibroblasts, demonstrating a direct role for this factor in tissue repair , Proceedings of the National Academy of Sciences , 98 , 11 , 6162 , 2001. Abstract Growth factors—for nerves and for epidermal tissue—are the areas of research of last year's recipients of the Nobel Prizes for Medicine. Role of nerve growth factor and other trophic factors in brain inflammation P. Murra, Fondazione Santa Lucia, Via Ardeatina 354, I-00179 Rome, Italy A.
The role of neurotrophins in bronchial asthma: contribution of the pan-neurotrophin receptor p75 H. Several chapters deal with the involvement of various neurotrophins in the control of different nonneuronal processes, such as immune, inflammatory and allergic reactions, tissue repair and wound healing. Zonta Turin and Padova, Italy 291 34 V. Acute and long-term synaptic modulation by neurotrophins B. Neural stem and progenitor cells: choosing the right Shc T. The allele and phenotype frequencies of the studied genetic variant in schizophrenia-affected and healthy subjects are shown in. Experimental and clinical evidence of neuroprotection by nerve growth factor eye drops: Implications for glaucoma.
Electronic Storage or Usage Permission of the Publisher is required to store or use electronically any material contained in this work, including any chapter or part of a chapter Except as outlined above, no part of this work may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior written permission of the Publisher. Haddad, Pamela Abou Jaoude, Suhayl J. Frs2, a scaffolding protein Kao et al. Giardino, Pathophysiology Center for Nervous System, Hesperia Hospital, I-41100 Modena, Italy A. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period.
Neurotrophins in spinal cord nociceptive pathways A. Neurotrophic factors and their receptors in human sensory neuropathies P. Remyelination in multiple sclerosis: a new role for neurotrophins? Growth factors and cell signaling 1. Viral vestor-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord W. They passed a special examination by two independent experienced psychiatrists to establish no personal or family history of mental disorders. The growth of nerves and of epidermal tissue requires a chemical stimulant. Discovering novel phenotype-selective neurotrophic factors to treat neurodegenerative diseases P.
Originally identified as neurite outgrowth-stimulating factor, later studies revealed that the purified molecule has a number of target cells in the central nervous system and on nonneuronal cells. Neurotrophins and the Immune System. Despite the brain's status as an immune privileged site, an extensive bi-directional communication takes place between the nervous and the immune system in both health and disease. Alfred North Whitehead 1861—1947 Growth factors are signaling proteins which play a crucial role in cell proliferation, differentiation and survival, and their functions are currently intensively studied in biomedical research. Crowder, Department of Pathology, Washington University School of Medicine, St.
Molecules with these activities include ciliary neurotrophic factor, glial cell line-derived neurotrophic factor, basic fibroblast growth factor, insulin-like growth factor, leukemia inhibitory factor, bone morphogenetic proteins and transforming growth factor-beta, to list a part of them only. The data were evaluated using GraphPad Prism 3. George Chaldakov from the Medical University, Varna, Bulgaria on a sabbatical visit and collaboration with Dr. Description: 1 online resource xviii, 544 pages : illustrations some color. The book highlights different aspects of current understanding of neurotrophin-receptor signal transduction pathways, including the signaling endosome hypothesis. Regino Perez-Polo, Effects of nerve growth factor on splenic norepinephrine and pineal N-acetyl-transferase in neonate rats exposed to alcohol in utero: Neuroimmune correlates , International Journal of Developmental Neuroscience , 14 , 5 , 655 , 1996.
Viral vestor-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord W. Colombo 3, 35121 Padova, Italy Preface Publisher Summary Growth factors are signaling proteins that play a crucial role in cell proliferation, differentiation, and survival, and their functions are studied in biomedical research. This is the third and concluding volume of the treatise on growth factors and cytokines in health and disease. Neurotrophins in the ear: their roles in sensory neuron survival and fiber guidance B. All these neurotrophins share significant structural homology and sometimes overlapping functions mediated by two classes of cell surface receptors. Teaching nursing home of Catholic University of the Sacred Heart, Italy.
No exhaustive explanations were provided for the outcomes of the last clinical trial. Giardino Bologna and Modena, Italy 75 18 6. Melanoma is a highly aggressive skin tumor that originates in the epidermis from melanocytes. The significance of differences between allele and phenotype frequencies in study groups was determined using Pearson's chi-square test. Neural crest development and neuroblastoma: the genetic and biological link A. Neurotrophin-3 in the development of the enteric nervous system A. In addition, diseases featured by immune, inflammatory and fibro proliferative reactions, such as corneal and skin ulcers, rheumatoid arthritis, systemic sclerosis, tumors, bronchial asthma, atherosclerotic cardiovascular disease and even hair growth disorders, appeared to be of potential interest for clinical evaluations.
This scientific research growth process resulted in the production of an enormous body of knowledge in the nervous system and more recently also in the pathogenesis of neuroimmune and auto immune inflammatory diseases. Author by : Victor R. Neurotrophic factors and psychiatric-like disorders: evidence in rodent models of schizophrenia and depression F. Braun Hannover and Marburg, Germany 347 22 23. Neural crest development and neuroblastoma: the genetic and biological link A.
Various cancers are examined in a number of the chapters. Study population A total of 475 unrelated Caucasian individuals of Armenian nationality living in Armenia 200 chronic schizophrenia patients, 25 first-episode schizophrenia patients and 250 healthy subjects were enrolled in this study. Bartlett Brisbane, Qld and Parkville, Vic. Neurotrophins in the ear: their roles in sensory neuron survival and fiber guidance B. Neurotrophins in spinal cord nociceptive pathways A. This volume is dedicated to the Nobel Laureate Professor Rita Levi—Montalcini, who discovered the first cell growth factor and opened up the field of trophic factors in the biomedical science.