Which of the following shows high first pass metabolism: a Propranolol b Phenobarbitone c Phenylbutazone d Phenytoin e Reflex esophagitis Ans:a 62. CiteScore values are based on citation counts in a given year e. The following drug is not secreted in bile a Penicillin b Phenolphthalein c Novobiocin d Erythromycin Ans:a 21. Click to view the full list of abbreviations that can be employed without definition. Which statement is false of Domperidone a Chemically related to haloperidol b Pharmacologically related to metoclopramide c Extra pyramidal symptoms are common d It counteracts the emetic action but not the therapeutic effect in parkinsonism Ans:c 75. Antiemitic used to prevent aspiration in emergency surgery a Ondansetrone b Promethazine c Metoclopromide d Ranitidine Ans: b 98. The book explains some of the experiments that tell us how drugs work, and it outlines the physiological and pathological context that make those action mechanisms therapeutically useful.
A summary declaration of interest statement in the title page file if double-blind or the manuscript file if single-blind. Please use this proof only for checking the typesetting, editing, completeness and correctness of the text, tables and figures. American spelling must be used, avoiding general and plural terms and multiple concepts. . Biochemical Pharmacology is intended primarily for students in biology and biochemistry at the advanced undergraduate or graduate levels. Are the sources of all materials clearly indicated? It is written in a conversational, vivid style that readily encourages students to explore this important area of medical science.
All of following are examples of prodrugs except a Levodopa b Enlapril c Omeprazole d Indomethacin Ans:d 7. The different kinds of Glycoconjugates include: Proteoglycans: In the Proteoglycans, the Glucosaminoglycan moety forms the greater fraction of the molecule tipically a proteoglycan consists of 95 % of carbohydrates and is the main site of biological activity, providing multiple binding sites. Drugs or other compounds should only be identified by their chemical or generic names. Which of the following is not a dose related reaction: a Myocardial Irritation of Quinidine b Hypoglycemia of tolbutamide c Digitalis induced arrythmia d Drug fever of sulpha Ans:d 56. Green open access Authors can share their research in a variety of different ways and Elsevier has a number of green open access options available.
Submissions describing work focused predominately on chemical synthesis and molecular modeling will not be considered for review. While medicinal chemistry is a topic of complimentary interest, manuscripts in this area must contain sufficient biological data to characterize pharmacologically the compounds reported. Preface Acknowledgments 1 Introduction 1. Xenobiotics is characterized by chemicals, such as drugs, that are inherently foreign to a living organism. The cannot be shared publicly, for example on ResearchGate or Academia. For individuals with late onset Pompe disease, the prognosis is dependent upon the age of onset. All the following induce hepatic enzymes except a Rifampicin b Phenytoin c Barbiturates d Tolbutamide Ans:d 61.
Most babies with Pompe disease die from cardiac or respiratory complications before their first birthday. The use of spell-check and grammar-check offered in the word processing software is highly recommended. Manuscripts describing experiments conducted with chemical mixtures, plant or animal extracts will not be considered for publication unless the chemical structures and precise concentrations of all substances are reported. Biochemical Pharmacology is intended primarily for students in biology and biochemistry at the advanced undergraduate or graduate levels. Regardless of how you choose to publish your article, the journal will apply the same peer review criteria and acceptance standards. Submission declaration and verification Submission of an article implies that the work described has not been published previously except in the form of an abstract, a published lecture or academic thesis, see '' for more information , that it is not under consideration for publication elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and that, if accepted, it will not be published elsewhere in the same form, in English or in any other language, including electronically without the written consent of the copyright-holder.
If the manuscript has already been published in an online issue, any requests approved by the Editor will result in a corrigendum. Alcohol should not be given with a Sulphonamides b Clonidine c Reserpine d Metronidazole Ans:d 22. Please note that your article will be reviewed again by the new journal. While medicinal chemistry is a topic of complimentary interest, manuscripts in this area must contain sufficient biological data to characterize pharmacologically the compounds reported. Any addition, deletion or rearrangement of author names in the authorship list should be made only before the manuscript has been accepted and only if approved by the journal Editor.
Preprints Please note that can be shared anywhere at any time, in line with Elsevier's. Web-based proofing provides a faster and less error-prone process by allowing you to directly type your corrections, eliminating the potential introduction of errors. An integrated approach to the study of drug action mechanisms Biochemical Pharmacology is a concise and contemporary textbook on the principles of drug action. Biochemical Pharmacology can also serve as an introduction for professionals in biosciences, as well as in pharmaceutical and health sciences. The book explains some of the experiments that tell us how drugs work, and it outlines the physiological and pathological context that make those action mechanisms therapeutically useful. The focus on a drug's direct biochemical effect on the human body began in the 1950s.
Beta blocker are used in all, except a Variant angina b Mild hypertension c Glaucoma d Thyrotoxicosis Ans:a 88. To pinpoint effective curative solutions, biochemical pharmacologists use drugs to discover new information about biosynthetic pathways and their kinetics. The materials can be downloaded in pdf format in: The content outlines for this exam has been updated by a subcommittee of the step I committee. Are the primary endpoints clearly stated? Complete with numerous figures throughout the text, which are also available separately as PowerPoint slides, Biochemical Pharmacology : Explains the role of pharmacodynamics, pharmacokinetics, and drug metabolism in drug action Provides representative examples from the pharmacology of cell excitation, hormones, nitric oxide, chemotherapy, and others Examines emerging applications of ribonucleic acids as drugs and drug targets Discusses what researchers need to know about the problems of drug distribution, elimination, and toxicity Biochemical Pharmacology is an important resource for anyone wishing to gain an in-depth understanding of drug action mechanisms and extremely useful for researchers wishing to explore some of the unanswered questions. Secobarbital and ethanol when given together show: a Additive sedative action b Reduced sedative action c Competitive antagonism d Chemical antagonism e None of the above Ans:a 12.
Ultimately, the prognosis is dependent upon the extent of respiratory muscle involvement. Which of the following is the antidote for the toxin Lead? Only in exceptional circumstances will the Editor consider the addition, deletion or rearrangement of authors after the manuscript has been accepted. Alternatively, the submission must be accompanied by a separate statement in English on institutional letterhead, which is signed by an official responsible for research activities for the institute from which the manuscript originates, verifying the corresponding author is affiliated with the research institution. For each drug discussed, the authors provide the biochemical concepts needed to understand its function. Cellular damage is caused mainly by accumulation of glycogen in the cytoplasm and the lysosomes.